| NCAAF | 11/18 18:00 | 7 | Wheaton Thunder v Mount St. Joseph Lions | L | 41-34 | |
| NCAAF | 11/11 18:30 | 1 | Rose Hulman Engineers v Mount St. Joseph Lions | W | 20-68 | |
| NCAAF | 11/04 17:30 | 1 | Bluffton Beavers v Mount St. Joseph Lions | W | 27-49 | |
| NCAAF | 10/28 17:30 | 1 | Mount St. Joseph Lions v Franklin College Grizzlies | W | 55-0 | |
| NCAAF | 10/21 17:30 | 1 | Mount St. Joseph Lions v Hanover Panthers | W | 52-27 | |
| NCAAF | 10/14 17:30 | 1 | Mount St. Joseph Lions v Anderson Ravens | W | 77-14 | |
| NCAAF | 10/07 17:30 | 1 | Defiance Yellow Jackets v Mount St. Joseph Lions | W | 21-62 | |
| NCAAF | 09/30 17:30 | 1 | Mount St. Joseph Lions v Manchester Spartans | W | 69-14 | |
| NCAAF | 09/16 17:00 | 1 | Hope Flying Dutchmen v Mount St. Joseph Lions | L | 40-35 | |
| NCAAF | 09/09 16:00 | 1 | Mount St. Joseph Lions v Hiram Terriers | W | 62-21 | |
| NCAAF | 09/02 17:30 | 1 | Baldwin Wallace Yellow Jackets v Mount St. Joseph Lions | W | 33-46 | |
| NCAAF | 11/19 17:00 | 7 | Alma College Scots v Mount St. Joseph Lions | L | 41-21 | |
| NCAAF | 11/12 18:30 | 1 | Mount St. Joseph Lions v Rose Hulman Engineers | W | 40-31 | |
| NCAAF | 11/05 17:30 | 1 | Franklin College Grizzlies v Mount St. Joseph Lions | W | 20-27 | |
| NCAAF | 10/29 17:30 | 1 | Mount St. Joseph Lions v Bluffton Beavers | W | 70-21 | |
| NCAAF | 10/22 17:30 | 1 | Hanover Panthers v Mount St. Joseph Lions | W | 29-44 | |
| NCAAF | 10/15 17:30 | 1 | Anderson Ravens v Mount St. Joseph Lions | W | 3-59 | |
| NCAAF | 10/08 17:30 | 1 | Mount St. Joseph Lions v Defiance Yellow Jackets | W | 55-35 | |
| NCAAF | 10/01 17:30 | 1 | Manchester Spartans v Mount St. Joseph Lions | W | 20-55 | |
| NCAAF | 09/17 17:30 | 1 | Mount St. Joseph Lions v Hope Flying Dutchmen | W | 33-28 | |
| NCAAF | 09/10 16:00 | 1 |
Alfred Saxons
v
Mount St. Joseph Lions
|
W | 37-43 | |
| NCAAF | 09/03 17:30 | 1 | Mount St. Joseph Lions v Baldwin Wallace Yellow Jackets | W | 31-28 | |
| NCAAF | 11/13 18:30 | 1 | Rose Hulman Engineers v Mount St. Joseph Lions | L | 58-21 | |
| NCAAF | 11/06 17:30 | 1 | Mount St. Joseph Lions v Hanover Panthers | W | 23-6 | |
| NCAAF | 10/30 17:30 | 1 | Mount St. Joseph Lions v Anderson Ravens | W | 35-18 | |
| NCAAF | 10/23 17:30 | 1 | Defiance Yellow Jackets v Mount St. Joseph Lions | L | 14-13 | |
| NCAAF | 10/16 17:30 | 1 | Mount St. Joseph Lions v Manchester Spartans | W | 28-0 | |
| NCAAF | 10/09 17:30 | 1 | Mount St. Joseph Lions v Franklin College Grizzlies | W | 28-14 | |
| NCAAF | 10/02 17:30 | 1 | Bluffton Beavers v Mount St. Joseph Lions | W | 27-45 | |
| NCAAF | 09/18 17:00 | 1 | Trine Thunder v Mount St. Joseph Lions | L | 31-30 |