| NCAAF | 09/25 19:00 | 1 | Tennessee State v SE Missouri State | W | 14-47 | |
| NCAAF | 09/18 16:00 | 1 |
[107] SE Missouri State
v
Missouri
[60] 
|
L | 28-59 | |
| NCAAF | 09/11 23:00 | 1 | SE Missouri State v Sam Houston State | L | 14-52 | |
| NCAAF | 09/02 23:30 | 1 | Southern Illinois v SE Missouri State | L | 47-21 | |
| NCAAF | 04/11 19:30 | 1 | SE Missouri State v Tennessee State | W | 46-23 | |
| NCAAF | 04/03 18:00 | 1 | SE Missouri State v Tennessee Martin | W | 21-16 | |
| NCAAF | 03/28 19:00 | 1 | Tennessee Tech v SE Missouri State | W | 21-24 | |
| NCAAF | 03/21 19:00 | 1 | SE Missouri State v Jacksonville State | L | 3-21 | |
| NCAAF | 03/14 19:00 | 1 |
Austin Peay
v
SE Missouri State
|
L | 49-42 | |
| NCAAF | 03/07 20:00 | 1 | Murray State v SE Missouri State | L | 24-21 | |
| NCAAF | 02/28 20:00 | 1 | Eastern Illinois v SE Missouri St | W | 7-47 | |
| NCAAF | 10/30 23:00 | 1 | SE Missouri State v Southern Illinois | L | 17-20 | |
| NCAAF | 11/30 19:00 | 7 | Illinois St v SE Missouri St | L | 24-6 | |
| NCAAF | 11/23 19:00 | 1 | Murray St v SE Missouri St | W | 24-31 | |
| NCAAF | 11/16 18:00 | 1 | SE Missouri St v Eastern Illinois | W | 26-12 | |
| NCAAF | 11/09 19:00 | 1 | Eastern Kentucky v SE Missouri St | W | 31-38 | |
| NCAAF | 11/02 19:00 | 1 | SE Missouri St v Tennessee State | W | 32-13 | |
| NCAAF | 10/26 18:00 | 1 | Tennessee Martin v SE Missouri St | W | 10-17 | |
| NCAAF | 10/19 20:00 | 1 | SE Missouri St v Jacksonville State | W | 24-21 | |
| NCAAF | 10/12 19:00 | 1 |
SE Missouri St
v
Austin Peay
|
L | 24-28 | |
| NCAAF | 10/05 23:00 | 1 | Tennessee Tech v SE Missouri St | W | 37-43 | |
| NCAAF | 09/21 18:00 | 1 | SE Missouri St v West Virginia State Yellow Jackets | W | 56-10 | |
| NCAAF | 09/14 23:30 | 1 |
SE Missouri State
v
Missouri
|
L | 0-50 | |
| NCAAF | 09/08 00:00 | 1 | SE Missouri State v Montana State | L | 17-38 | |
| NCAAF | 08/29 23:30 | 1 | Southern Illinois v SE Missouri St | W | 26-44 | |
| NCAAF FCS | 12/01 21:00 | 8 | SE Missouri St v Weber St | L | 23-48 | |
| NCAAF FCS | 11/24 19:00 | 7 | Stony Brook v SE Missouri St | W | 14-28 | |
| NCAAF FCS | 11/17 19:00 | 1 | Eastern Illinois v SE Missouri St | W | 32-38 | |
| NCAAF FCS | 11/10 17:00 | 1 | SE Missouri St v Murray St | L | 38-40 | |
| NCAAF FCS | 11/03 18:00 | 1 | Tennessee State v SE Missouri St | W | 21-38 |