[21] PIT Penguins 3-6 BUF Sabres [8] 2022-11-02 23:30
Stadion: KeyBank Center
Home Manager: Don Granato Away Manager: Mike Sullivan
Head to Head
| NHL - Pre-Season | 2022/10/07 23:00 | BUF Sabres v PIT Penguins | W | 1-7 |
| NHL - Pre-Season | 2022/10/01 17:00 | PIT Penguins v BUF Sabres | L | 1-3 |
| NHL | 2022/03/23 23:30 | PIT Penguins v BUF Sabres | L | 3-4 |
| NHL | 2021/12/18 00:00 | BUF Sabres v PIT Penguins | W | 2-3 |
| NHL | 2021/11/17 00:00 | BUF Sabres v PIT Penguins | L | 2-1 |
| NHL - Pre-Season | 2021/10/05 23:00 | BUF Sabres v PIT Penguins | W | 4-5 |
| NHL - Pre-Season | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | W | 2-1 |
| NHL | 2021/05/08 19:00 | BUF Sabres v PIT Penguins | W | 0-1 |
Home History
| NHL | 2022/11/02 00:00 | BOS Bruins v PIT Penguins | L | 6-5 |
| NHL | 2022/10/30 02:00 | PIT Penguins v SEA Kraken | L | 1-3 |
| NHL | 2022/10/29 02:00 | PIT Penguins v VAN Canucks | L | 1-5 |
| NHL | 2022/10/26 01:00 | PIT Penguins v CAL Flames | L | 1-4 |
| NHL | 2022/10/25 00:00 | PIT Penguins v EDM Oilers | L | 3-6 |
| NHL | 2022/10/22 23:00 | PIT Penguins v CLB Blue Jackets | W | 6-3 |
| NHL | 2022/10/20 23:00 | LA Kings v PIT Penguins | W | 1-6 |
| NHL | 2022/10/17 23:00 | PIT Penguins v MON Canadiens | L | 2-3 |
Away History
| NHL | 2022/10/31 23:00 | DET Red Wings v BUF Sabres | W | 3-8 |
| NHL | 2022/10/29 23:00 | CHI Blackhawks v BUF Sabres | W | 3-4 |
| NHL | 2022/10/27 23:00 | MON Canadiens v BUF Sabres | L | 3-2 |
| NHL | 2022/10/26 02:00 | BUF Sabres v SEA Kraken | L | 1-5 |
| NHL | 2022/10/23 02:00 | BUF Sabres v VAN Canucks | W | 5-1 |
| NHL | 2022/10/21 01:30 | BUF Sabres v CAL Flames | W | 6-3 |
| NHL | 2022/10/19 01:00 | BUF Sabres v EDM Oilers | W | 4-2 |
| NHL | 2022/10/15 17:00 | FLA Panthers v BUF Sabres | L | 4-3 |