[13] DET Red Wings 3-8 BUF Sabres [12] 2022-10-31 23:00
Stadion: KeyBank Center
Home Manager: Don Granato Away Manager: Derek Lalonde
Head to Head
| NHL | 2022/01/17 18:00 | DET Red Wings v BUF Sabres | W | 3-2 |
| NHL | 2022/01/16 00:00 | BUF Sabres v DET Red Wings | W | 0-4 |
| NHL | 2021/11/28 00:00 | BUF Sabres v DET Red Wings | W | 2-3 |
| NHL | 2021/11/06 23:00 | DET Red Wings v BUF Sabres | W | 4-3 |
| NHL - Pre-Season | 2021/10/09 19:00 | DET Red Wings v BUF Sabres | L | 1-3 |
| NHL - Pre-Season | 2021/09/30 23:30 | BUF Sabres v DET Red Wings | W | 2-6 |
| NHL | 2020/02/12 00:00 | DET Red Wings v BUF Sabres | L | 2-3 |
| NHL | 2020/02/07 00:00 | DET Red Wings v BUF Sabres | W | 4-3 |
Home History
| NHL | 2022/10/29 23:00 | MIN Wild v DET Red Wings | W | 1-2 |
| NHL | 2022/10/27 23:00 | DET Red Wings v BOS Bruins | L | 1-5 |
| NHL | 2022/10/25 23:00 | NJ Devils v DET Red Wings | L | 6-2 |
| NHL | 2022/10/23 21:00 | ANA Ducks v DET Red Wings | W | 1-5 |
| NHL | 2022/10/22 00:30 | DET Red Wings v CHI Blackhawks | L | 3-4 |
| NHL | 2022/10/17 23:00 | LA Kings v DET Red Wings | L | 5-4 |
| NHL | 2022/10/15 23:00 | DET Red Wings v NJ Devils | W | 5-2 |
| NHL | 2022/10/14 23:00 | MON Canadiens v DET Red Wings | W | 0-3 |
Away History
| NHL | 2022/10/29 23:00 | CHI Blackhawks v BUF Sabres | W | 3-4 |
| NHL | 2022/10/27 23:00 | MON Canadiens v BUF Sabres | L | 3-2 |
| NHL | 2022/10/26 02:00 | BUF Sabres v SEA Kraken | L | 1-5 |
| NHL | 2022/10/23 02:00 | BUF Sabres v VAN Canucks | W | 5-1 |
| NHL | 2022/10/21 01:30 | BUF Sabres v CAL Flames | W | 6-3 |
| NHL | 2022/10/19 01:00 | BUF Sabres v EDM Oilers | W | 4-2 |
| NHL | 2022/10/15 17:00 | FLA Panthers v BUF Sabres | L | 4-3 |
| NHL | 2022/10/13 23:00 | OTT Senators v BUF Sabres | W | 1-4 |