[7] DET Red Wings 4-3 BUF Sabres [4] 2021-11-06 23:00
Stadion: KeyBank Center
Home Manager: Don Granato Away Manager: Jeff Blashill
Head to Head
| NHL - Pre-Season | 2021/10/09 19:00 | DET Red Wings v BUF Sabres | L | 1-3 |
| NHL - Pre-Season | 2021/09/30 23:30 | BUF Sabres v DET Red Wings | W | 2-6 |
| NHL | 2020/02/12 00:00 | DET Red Wings v BUF Sabres | L | 2-3 |
| NHL | 2020/02/07 00:00 | DET Red Wings v BUF Sabres | W | 4-3 |
| NHL | 2020/01/12 22:00 | BUF Sabres v DET Red Wings | L | 5-1 |
| NHL | 2019/10/25 23:30 | BUF Sabres v DET Red Wings | L | 2-0 |
| NHL | 2019/04/06 23:00 | BUF Sabres v DET Red Wings | L | 7-1 |
| NHL | 2019/03/28 23:00 | DET Red Wings v BUF Sabres | W | 5-4 |
Home History
| NHL | 2021/11/04 23:00 | DET Red Wings v BOS Bruins | L | 1-5 |
| NHL | 2021/11/02 23:00 | DET Red Wings v MON Canadiens | L | 0-3 |
| NHL | 2021/10/30 23:00 | DET Red Wings v TOR Maple Leafs | L | 4-5 |
| NHL | 2021/10/29 23:00 | FLA Panthers v DET Red Wings | L | 3-2 |
| NHL | 2021/10/27 23:00 | DET Red Wings v WAS Capitals | W | 3-2 |
| NHL | 2021/10/24 23:00 | DET Red Wings v CHI Blackhawks | W | 6-3 |
| NHL | 2021/10/23 23:00 | DET Red Wings v MON Canadiens | L | 1-6 |
| NHL | 2021/10/21 23:30 | CAL Flames v DET Red Wings | L | 3-0 |
Away History
| NHL | 2021/11/05 02:00 | BUF Sabres v SEA Kraken | L | 2-5 |
| NHL | 2021/11/03 02:30 | BUF Sabres v SJ Sharks | L | 3-5 |
| NHL | 2021/10/31 20:00 | BUF Sabres v LA Kings | L | 2-3 |
| NHL | 2021/10/29 02:00 | BUF Sabres v ANA Ducks | W | 4-3 |
| NHL | 2021/10/25 23:00 | TB Lightning v BUF Sabres | W | 1-5 |
| NHL | 2021/10/23 23:00 | BUF Sabres v NJ Devils | L | 1-2 |
| NHL | 2021/10/22 23:00 | BOS Bruins v BUF Sabres | L | 4-1 |
| NHL | 2021/10/19 23:00 | VAN Canucks v BUF Sabres | W | 2-5 |