Stadion: Houck Stadium Round: 1
Home Manager: Tom Matukewicz Away Manager: Jason Simpson
| NCAAF | 2021/10/23 19:00 | SE Missouri St v Tennessee Martin | W | 30-38 |
| NCAAF | 2021/04/03 18:00 | SE Missouri St v Tennessee Martin | L | 21-16 |
| NCAAF | 2019/10/26 18:00 | Tennessee Martin v SE Missouri St | L | 10-17 |
| NCAAF | 2018/10/27 19:00 | Tennessee Martin v SE Missouri St | L | 33-56 |
| NCAAF | 2017/11/04 18:00 | SE Missouri St v Tennessee Martin | W | 14-16 |
| NCAAF | 2021/11/13 19:30 | Tennessee Martin v Tennessee Tech | W | 42-3 |
| NCAAF | 2021/11/06 19:00 | Tennessee State v Tennessee Martin | W | 20-41 |
| NCAAF | 2021/10/30 19:00 | Austin Peay v Tennessee Martin | W | 16-17 |
| NCAAF | 2021/10/23 19:00 | SE Missouri St v Tennessee Martin | W | 30-38 |
| NCAAF | 2021/10/16 19:00 | Tennessee Martin v Eastern Illinois | W | 28-17 |
| NCAAF | 2021/10/09 19:00 | Murray State v Tennessee Martin | W | 24-48 |
| NCAAF | 2021/09/25 20:00 | Tennessee Martin v Jacksonville State | W | 34-31 |
| NCAAF | 2021/09/18 23:00 | Tennessee Martin v Northwestern State | W | 35-10 |
| NCAAF | 2021/11/13 19:00 | SE Missouri St v Murray State | L | 10-28 |
| NCAAF | 2021/10/30 18:00 | Eastern Illinois v SE Missouri St | W | 15-38 |
| NCAAF | 2021/10/23 19:00 | SE Missouri St v Tennessee Martin | L | 30-38 |
| NCAAF | 2021/10/16 19:00 | Murray State v SE Missouri St | L | 32-31 |
| NCAAF | 2021/10/09 20:00 | SE Missouri St v Austin Peay | W | 30-14 |
| NCAAF | 2021/10/02 18:30 | SE Missouri St v Tennessee Tech | L | 17-28 |
| NCAAF | 2021/09/25 19:00 | Tennessee State v SE Missouri St | W | 14-47 |
| NCAAF | 2021/09/18 16:00 | SE Missouri St v Missouri | L | 28-59 |