| Challenger - Charlottesville | 11/02 22:00 | 26 | Aidan Mayo v Reilly Opelka | Walkover | |
| Challenger - Charlottesville | 11/01 00:15 | 25 | Reilly Opelka v Tennys Sandgren | 6-4,7-5 | |
| ATP - Washington | 08/04 21:45 | 26 | [63] Nick Kyrgios v Reilly Opelka [17] | 7-6,6-2 | |
| ATP - Washington | 08/03 23:30 | 25 | [82] Denis Kudla v Reilly Opelka [17] | 7-6,4-6,4-6 | |
| ATP - Atlanta | 07/27 23:00 | 26 | Reilly Opelka v Ilya Ivashka | Cancelled | |
| Wimbledon | 06/29 16:30 | 24 | [104] Tim Van Rijthoven v Reilly Opelka [18] | 6-4,6-7,7-6,7-6 | |
| Wimbledon | 06/27 17:40 | 23 | [98] Carlos Taberner v Reilly Opelka [18] | 6-7,4-6,4-6 | |
| ATP - Eastbourne | 06/20 10:00 | 25 | [60] Maxime Cressy v Reilly Opelka [18] | 6-3,6-1 | |
| ATP - Queens | 06/13 11:00 | 25 | [18] Reilly Opelka v Alex De Minaur [21] | 4-6,4-6 | |
| French Open | 05/23 09:00 | 23 | [55] Filip Krajinovic v Reilly Opelka [17] | 7-6,6-2,6-3 | |
| ATP - Genf | 05/20 12:15 | 28 | [18] Reilly Opelka v Casper Ruud [8] | 6-7,5-7 | |
| ATP - Genf | 05/19 11:30 | 27 | [64] Tallon Griekspoor v Reilly Opelka [18] | 4-6,6-3,3-6 | |
| ATP - Genf | 05/18 10:00 | 26 | [124] Christopher O'Connell v Reilly Opelka [18] | 3-6,5-7 | |
| ATP - Rom | 05/09 09:00 | 24 | [361] Stan Wawrinka v Reilly Opelka [17] | 3-6,7-5,6-2 | |
| ATP - Madrid | 05/03 18:20 | 24 | [17] Reilly Opelka v Sebastian Korda [30] | 3-6,5-7 | |
| ATP - München | 04/28 13:30 | 26 | [17] Reilly Opelka v Oscar Otte [62] | 6-7,2-6 | |
| ATP - Houston | 04/10 19:00 | 29 | [18] Reilly Opelka v John Isner [27] | 6-3,7-6 | |
| ATP - Houston | 04/09 18:00 | 28 | [94] Nick Kyrgios v Reilly Opelka [18] | 3-6,5-7 | |
| ATP - Houston | 04/08 17:00 | 27 | [18] Reilly Opelka v Gijs Brouwer [361] | 6-3,7-5 | |
| ATP - Houston | 04/06 23:00 | 26 | [18] Reilly Opelka v Mitchell Krueger [161] | 3-6,6-2,6-4 | |
| ATP - Miami | 03/25 21:15 | 24 | [18] Reilly Opelka v Francisco Cerundolo [103] | Retired | |
| ATP - Indian Wells | 03/16 20:45 | 26 | [4] Rafael Nadal v Reilly Opelka [17] | 7-6,7-6 | |
| ATP - Indian Wells | 03/14 22:30 | 25 | [17] Reilly Opelka v Denis Shapovalov [13] | 6-7,6-4,6-4 | |
| ATP - Indian Wells | 03/12 20:50 | 24 | [17] Reilly Opelka v Lorenzo Musetti [56] | 6-1,6-4 | |
| ATP - Delray Beach | 02/20 20:00 | 29 | [13] Cameron Norrie v Reilly Opelka [20] | 7-6,7-6 | |
| ATP - Delray Beach | 02/20 01:00 | 28 | John Millman v Reilly Opelka | 6-7,7-6,6-7 | |
| ATP - Delray Beach | 02/18 23:00 | 27 | [53] Adrian Mannarino v Reilly Opelka [20] | 6-7,6-3,1-6 | |
| ATP - Delray Beach | 02/17 19:45 | 26 | [141] Jack Sock v Reilly Opelka [20] | 7-6,6-7,1-6 | |
| ATP - Dallas | 02/13 19:00 | 29 | [54] Jenson Brooksby v Reilly Opelka [23] | 6-7,6-7 | |
| ATP - Dallas | 02/12 22:00 | 28 | [26] John Isner v Reilly Opelka [23] | 6-7,6-7 |
Wikipedia - Reilly Opelka
Reilly Opelka (* 28. August 1997 in St. Joseph, Michigan) ist ein US-amerikanischer Tennisspieler.