| ITF Damen - Macon | 10/27 19:30 | 28 | [162] Varvara Lepchenko v Allie Kiick [171] | 6-4,6-2 | |
| ITF Damen - Macon | 10/27 15:40 | 27 | [193] Danielle Lao v Varvara Lepchenko [162] | 2-6,5-7 | |
| ITF Damen - Macon | 10/25 13:30 | 26 | [162] Varvara Lepchenko v Whitney Osuigwe [323] | 6-4,6-0 | |
| ITF Damen - Macon | 10/24 14:00 | 25 | [216] Ashley Kratzer v Varvara Lepchenko [162] | 1-6,3-6 | |
| WTA - Luxemburg | 10/16 19:00 | 25 | [66] Dayana Yastremska v Varvara Lepchenko [168] | 6-2,6-7,7-6 | |
| WTA - Luxemburg | 10/15 08:00 | 54 | [47] Belinda Bencic v Varvara Lepchenko [168] | 6-3,7-5 | |
| WTA - Luxemburg | 10/14 09:40 | 46 | [161] Varvara Lepchenko v Isabella Shinikova [270] | 3-6,6-4,6-3 | |
| WTA - Luxemburg | 10/13 13:05 | 45 | [161] Varvara Lepchenko v Patty Schnyder [234] | 6-4,6-2 | |
| WTA - Tianjin | 10/08 06:40 | 25 | [6] Karolina Pliskova v Varvara Lepchenko [161] | 6-2,6-7,6-3 | |
| WTA - Peking | 09/28 04:45 | 45 | [57] Sorana Cirstea v Varvara Lepchenko [105] | 4-6,6-4,7-6 | |
| WTA - Quebec City | 09/14 17:40 | 27 | [110] Varvara Lepchenko v Pauline Parmentier [69] | 6-7,1-6 | |
| WTA - Quebec City | 09/13 00:50 | 26 | [110] Varvara Lepchenko v Marie Bouzkova [163] | 6-1,1-6,6-3 | |
| WTA - Quebec City | 09/11 23:00 | 25 | [20] Aryna Sabalenka v Varvara Lepchenko [110] | 4-6,6-7 | |
| WTA - Chicago | 09/07 19:15 | 27 | [118] Varvara Lepchenko v Petra Martic [47] | 5-7,6-7 | |
| WTA - Chicago | 09/06 19:00 | 26 | [88] Sara Sorribes Tormo v Varvara Lepchenko [118] | 4-6,7-6,4-6 | |
| WTA - Chicago | 09/05 20:05 | 25 | [104] Katie Boulter v Varvara Lepchenko [118] | Retired | |
| US Open - Damen | 08/23 16:40 | 45 | [118] Varvara Lepchenko v Martina Trevisan [177] | 2-6,6-1,5-7 | |
| US Open - Damen | 08/21 21:55 | 44 | [118] Varvara Lepchenko v Katerina Stewart [262] | 6-2,6-1 | |
| WTA - Cincinnati | 08/14 17:15 | 24 | [46] Kaia Kanepi v Varvara Lepchenko [120] | 2-6,6-3,6-1 | |
| WTA Cincinnati Qual | 08/12 14:00 | 45 | [98] Christina McHale v Varvara Lepchenko [105] | 3-6,6-2,2-6 | |
| WTA Cincinnati Qual | 08/11 14:00 | 44 | [105] Varvara Lepchenko v Sachia Vickery [73] | 4-6,6-3,6-4 | |
| Wimbledon - Damen | 07/02 13:35 | 23 | [97] Varvara Lepchenko v Caroline Wozniacki [2] | 0-6,3-6 | |
| French Open - Frauen | 05/29 13:15 | 23 | [88] Varvara Lepchenko v Elise Mertens [16] | 7-6,6-7,0-6 | |
| WTA - Nürnberg | 05/20 14:50 | 25 | [98] Madison Brengle v Varvara Lepchenko [89] | 6-1,6-3 | |
| WTA - Rom - Qualifikation | 05/12 13:05 | 45 | [49] Danielle Collins v Varvara Lepchenko [89] | 6-2,6-3 | |
| WTA - Stuttgart - Qualifikation | 04/23 09:30 | 54 | [193] Veronika Kudermetova v Varvara Lepchenko [74] | 6-2,6-4 | |
| WTA - Stuttgart - Qualifikation | 04/22 09:00 | 46 | [367] Lena Rueffer v Varvara Lepchenko [74] | 4-6,1-6 | |
| WTA - Stuttgart - Qualifikation | 04/21 08:00 | 45 | [140] Magdalena Frech v Varvara Lepchenko [74] | 2-6,6-7 | |
| WTA - Charleston | 04/03 18:55 | 25 | [7] Caroline Garcia v Varvara Lepchenko [72] | 6-2,6-3 | |
| WTA - Charleston | 04/02 15:25 | 24 | [72] Varvara Lepchenko v Andrea Petkovic [99] | 6-4,7-5 |