[9] NY Islanders 3-5 BUF Sabres [5] 2022-04-23 16:30
Stadion: KeyBank Center
Home Manager: Don Granato Away Manager: Barry Trotz
Head to Head
| NHL | 2022/02/16 00:00 | NY Islanders v BUF Sabres | L | 3-6 |
| NHL | 2021/12/31 00:30 | BUF Sabres v NY Islanders | W | 1-4 |
| NHL | 2021/05/04 23:00 | NY Islanders v BUF Sabres | L | 3-4 |
| NHL | 2021/05/03 23:00 | NY Islanders v BUF Sabres | L | 2-4 |
| NHL | 2021/03/07 17:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/06 18:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/05 00:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/02/23 00:00 | BUF Sabres v NY Islanders | W | 2-3 |
| NHL | 2021/02/17 00:00 | NY Islanders v BUF Sabres | W | 3-0 |
| NHL | 2021/02/16 00:00 | NY Islanders v BUF Sabres | W | 3-1 |
| NHL | 2019/12/14 18:00 | BUF Sabres v NY Islanders | W | 2-3 |
| NHL | 2019/11/02 23:00 | NY Islanders v BUF Sabres | W | 1-0 |
| NHL | 2019/03/30 23:00 | BUF Sabres v NY Islanders | W | 1-5 |
| NHL | 2019/02/13 00:00 | NY Islanders v BUF Sabres | L | 1-3 |
| NHL | 2018/12/31 23:00 | NY Islanders v BUF Sabres | W | 3-1 |
| NHL - Pre-Season | 2018/09/28 23:00 | BUF Sabres v NY Islanders | L | 5-4 |
| NHL | 2018/02/09 00:00 | NY Islanders v BUF Sabres | L | 3-4 |
| NHL | 2017/12/28 00:00 | BUF Sabres v NY Islanders | W | 2-3 |
| NHL | 2017/10/07 23:00 | NY Islanders v BUF Sabres | W | 6-3 |
| NHL - Pre-Season | 2017/09/29 23:00 | NY Islanders v BUF Sabres | W | 3-1 |
| NHL | 2017/04/02 19:00 | NY Islanders v BUF Sabres | W | 4-2 |
| NHL | 2016/12/24 00:00 | BUF Sabres v NY Islanders | W | 1-5 |
| NHL | 2016/12/17 00:00 | NY Islanders v BUF Sabres | L | 2-3 |