[9] Guairena FC 0-2 Cerro Porteño [2] 2021-10-25 21:30
Stadion: Estadio Parque del Guaira Round: 13
Schiedsrichter: Juan Gabriel Benitez Home Manager: Troadio Daniel Duarte Away Manager: Francisco Arce
Head to Head
| Paraguay - División Profesional | 2021/08/07 23:30 | Cerro Porteño v Guairena FC | L | 2-0 |
| Paraguay - División Profesional | 2021/04/25 21:45 | Guairena FC v Cerro Porteño | L | 0-1 |
| Paraguay - División Profesional | 2021/02/21 21:30 | Cerro Porteño v Guairena FC | D | 2-2 |
| Paraguay - División Profesional | 2020/11/07 21:15 | Guairena FC v Cerro Porteño | D | 1-1 |
| Paraguay - División Profesional | 2020/08/26 21:00 | Guairena FC v Cerro Porteño | L | 1-2 |
| Paraguay - División Profesional | 2020/02/15 22:15 | Cerro Porteño v Guairena FC | D | 2-2 |