[7] Tottenham 2-3 Southampton [12] 2022-02-09 19:45
Stadion: Tottenham Hotspur Stadium Round: 24
Schiedsrichter: David Coote Home Manager: Antonio Conte Away Manager: Ralph Hasenhüttl
Head to Head
| England - Premier League | 2021/12/28 15:00 | Southampton v Tottenham | D | 1-1 |
| England - Premier League | 2021/04/21 17:00 | Tottenham v Southampton | W | 2-1 |
| England - Premier League | 2020/09/20 11:00 | Southampton v Tottenham | W | 2-5 |
| England - FA Cup | 2020/02/05 19:45 | Tottenham v Southampton | W | 3-2 |
| England - FA Cup | 2020/01/25 15:00 | Southampton v Tottenham | D | 1-1 |
| England - Premier League | 2020/01/01 15:00 | Southampton v Tottenham | L | 1-0 |
| England - Premier League | 2019/09/28 14:00 | Tottenham v Southampton | W | 2-1 |
| England - Premier League | 2019/03/09 15:00 | Southampton v Tottenham | L | 2-1 |
| England - Premier League | 2018/12/05 20:00 | Tottenham v Southampton | W | 3-1 |
| England - Premier League | 2018/01/21 16:00 | Southampton v Tottenham | D | 1-1 |
| England - Premier League | 2017/12/26 12:30 | Tottenham v Southampton | W | 5-2 |
| England - Premier League | 2017/03/19 14:15 | Tottenham v Southampton | W | 2-1 |
| England - Premier League | 2016/12/28 19:45 | Southampton v Tottenham | W | 1-4 |
| England - Premier League | 2016/05/08 12:30 | Tottenham v Southampton | L | 1-2 |
| England - Premier League | 2015/12/19 15:00 | Southampton v Tottenham | W | 0-2 |
| England - Premier League | 2015/04/25 11:45 | Southampton v Tottenham | D | 2-2 |
| England - Premier League | 2014/10/05 13:05 | Tottenham v Southampton | W | 1-0 |