| Uruguay - Reserveliga | 2022/05/02 18:00 | Defensor Sporting - Reserve v Atletico Fenix - Reserve | L | 0-2 |
| Uruguay - Reserveliga | 2022/04/05 19:00 | Defensor Sporting - Reserve v Atletico River Plate - Reserve | L | 0-2 |
| Uruguay - Reserveliga | 2022/03/29 19:00 | Boston River - Reserve v Defensor Sporting - Reserve | D | 1-1 |
| Uruguay - Reserveliga | 2022/03/22 18:00 | Defensor Sporting - Reserve v Plaza Colonia - Reserve | W | 3-0 |
| Uruguay - Reserveliga | 2022/03/15 19:30 | Montevideo Wanderers - Reserve v Defensor Sporting - Reserve | L | 3-1 |
| Uruguay - Reserveliga | 2022/03/01 19:30 | Defensor Sporting - Reserve v Torque - Reserve | L | 2-3 |
| Uruguay - Reserveliga | 2022/02/14 19:30 | Defensor Sporting - Reserve v Liverpool Montevideo - Reserve | L | 1-2 |
| Uruguay - Reserveliga | 2021/12/07 19:00 | Defensor Sporting - Reserve v Juventud De Las Piedras - Reserve | L | 0-1 |
| Uruguay - Reserveliga | 2022/05/03 13:00 | Penarol - Reserve v Cerrito - Reserve | L | 1-0 |
| Uruguay - Reserveliga | 2022/04/18 18:30 | Atletico Fenix - Reserve v Cerrito - Reserve | L | 3-2 |
| Uruguay - Reserveliga | 2022/04/05 19:00 | Cerrito - Reserve v Liverpool Montevideo - Reserve | D | 0-0 |
| Uruguay - Reserveliga | 2022/03/21 19:00 | Cerrito - Reserve v Rentistas - Reserve | D | 2-2 |
| Uruguay - Reserveliga | 2022/03/15 13:30 | Atletico River Plate - Reserve v Cerrito - Reserve | L | 3-0 |
| Uruguay - Reserveliga | 2022/03/01 19:30 | Cerrito - Reserve v Deportivo Maldonado - Reserve | W | 2-1 |
| Uruguay - Reserveliga | 2022/02/22 19:30 | Boston River - Reserve v Cerrito - Reserve | W | 1-2 |
| Uruguay - Reserveliga | 2022/02/15 19:30 | Cerrito - Reserve v Danubio - Reserve | L | 1-3 |