[18] Tranmere 2-1 Leyton Orient [16] 2017-10-04 18:45
Weer: Gut Stadion: Prenton Park Spielfeld: Gut Round: 14
Home History
| England - National League | 2017/09/30 14:00 | Bromley v Tranmere | W | 0-1 |
| England - National League | 2017/09/23 14:00 | Tranmere v Wrexham | L | 0-1 |
| England - National League | 2017/09/16 14:00 | Ebbsfleet United v Tranmere | D | 0-0 |
| England - National League | 2017/09/12 18:45 | Maidenhead Utd v Tranmere | L | 1-0 |
| England - National League | 2017/09/09 14:00 | Tranmere v Barrow | W | 1-0 |
| England - National League | 2017/09/02 16:30 | Tranmere v Dover | L | 0-1 |
| England - National League | 2017/08/28 14:00 | Solihull Moors v Tranmere | W | 0-2 |
| England - National League | 2017/08/26 14:00 | Tranmere v Boreham Wood | D | 2-2 |
Away History
| England - National League | 2017/09/30 14:00 | Leyton Orient v AFC Fylde | L | 1-2 |
| England - National League | 2017/09/23 14:00 | Aldershot v Leyton Orient | D | 2-2 |
| England - National League | 2017/09/16 11:30 | Leyton Orient v Hartlepool | L | 1-2 |
| England - National League | 2017/09/12 18:45 | Leyton Orient v Halifax | L | 0-3 |
| England - National League | 2017/09/09 14:00 | Boreham Wood v Leyton Orient | L | 2-0 |
| England - National League | 2017/09/02 14:00 | Leyton Orient v Guiseley | W | 4-1 |
| England - National League | 2017/08/28 14:00 | Maidenhead Utd v Leyton Orient | W | 0-1 |
| England - National League | 2017/08/26 14:00 | Leyton Orient v Eastleigh | D | 1-1 |