[11] NY Islanders 3-6 BUF Sabres [7] 2022-02-16 00:00
Stadion: KeyBank Center
Home Manager: Don Granato Away Manager: Barry Trotz
Head to Head
| NHL | 2021/12/31 00:30 | BUF Sabres v NY Islanders | W | 1-4 |
| NHL | 2021/05/04 23:00 | NY Islanders v BUF Sabres | L | 3-4 |
| NHL | 2021/05/03 23:00 | NY Islanders v BUF Sabres | L | 2-4 |
| NHL | 2021/03/07 17:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/06 18:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/03/05 00:00 | BUF Sabres v NY Islanders | W | 2-5 |
| NHL | 2021/02/23 00:00 | BUF Sabres v NY Islanders | W | 2-3 |
| NHL | 2021/02/17 00:00 | NY Islanders v BUF Sabres | W | 3-0 |
Home History
| NHL | 2022/02/13 03:00 | NY Islanders v CAL Flames | L | 2-5 |
| NHL | 2022/02/12 02:00 | NY Islanders v EDM Oilers | L | 1-3 |
| NHL | 2022/02/10 03:30 | NY Islanders v VAN Canucks | W | 6-3 |
| NHL | 2022/02/03 00:00 | SEA Kraken v NY Islanders | L | 3-0 |
| NHL | 2022/02/02 00:30 | OTT Senators v NY Islanders | W | 1-4 |
| NHL | 2022/01/31 00:30 | MIN Wild v NY Islanders | L | 4-3 |
| NHL | 2022/01/28 00:00 | LA Kings v NY Islanders | L | 3-2 |
| NHL | 2022/01/26 00:30 | PHI Flyers v NY Islanders | W | 3-4 |
Away History
| NHL | 2022/02/13 17:30 | BUF Sabres v MON Canadiens | W | 5-3 |
| NHL | 2022/02/11 00:00 | CLB Blue Jackets v BUF Sabres | L | 4-3 |
| NHL | 2022/02/02 03:00 | BUF Sabres v VGS Golden Knights | L | 2-5 |
| NHL | 2022/01/31 01:00 | BUF Sabres v COL Avalanche | L | 1-4 |
| NHL | 2022/01/30 02:00 | BUF Sabres v ARZ Coyotes | W | 3-1 |
| NHL | 2022/01/26 00:00 | BUF Sabres v OTT Senators | L | 0-5 |
| NHL | 2022/01/22 18:00 | PHI Flyers v BUF Sabres | W | 3-6 |
| NHL | 2022/01/21 00:00 | DAL Stars v BUF Sabres | L | 5-4 |