[3] CAR Hurricanes 2-4 BUF Sabres [25] 2022-04-05 23:00
Stadion: KeyBank Center
Home Manager: Don Granato Away Manager: Rod Brind'Amour
Head to Head
| NHL | 2021/12/05 00:30 | BUF Sabres v CAR Hurricanes | W | 2-6 |
| NHL | 2019/11/15 00:00 | CAR Hurricanes v BUF Sabres | W | 5-4 |
| NHL | 2019/03/16 23:00 | BUF Sabres v CAR Hurricanes | W | 2-4 |
| NHL | 2019/02/08 00:00 | CAR Hurricanes v BUF Sabres | W | 6-5 |
| NHL | 2019/01/12 00:30 | BUF Sabres v CAR Hurricanes | W | 3-4 |
| NHL | 2017/12/24 00:00 | BUF Sabres v CAR Hurricanes | W | 2-4 |
| NHL | 2017/12/16 00:00 | CAR Hurricanes v BUF Sabres | W | 5-4 |
| NHL | 2017/11/19 00:00 | CAR Hurricanes v BUF Sabres | W | 3-1 |
Home History
| NHL | 2022/04/02 23:00 | MIN Wild v CAR Hurricanes | L | 3-1 |
| NHL | 2022/03/31 23:00 | MON Canadiens v CAR Hurricanes | W | 0-4 |
| NHL | 2022/03/29 23:00 | CAR Hurricanes v TB Lightning | L | 3-4 |
| NHL | 2022/03/28 23:00 | CAR Hurricanes v WAS Capitals | W | 6-1 |
| NHL | 2022/03/27 00:00 | CAR Hurricanes v STL Blues | W | 7-2 |
| NHL | 2022/03/24 23:00 | DAL Stars v CAR Hurricanes | L | 4-3 |
| NHL | 2022/03/22 23:00 | TB Lightning v CAR Hurricanes | W | 2-3 |
| NHL | 2022/03/20 22:00 | NY Rangers v CAR Hurricanes | L | 2-0 |
Away History
| NHL | 2022/04/03 17:00 | FLA Panthers v BUF Sabres | L | 5-3 |
| NHL | 2022/04/01 23:00 | NAS Predators v BUF Sabres | W | 3-4 |
| NHL | 2022/03/30 23:00 | WIN Jets v BUF Sabres | L | 3-2 |
| NHL | 2022/03/29 00:30 | BUF Sabres v CHI Blackhawks | W | 6-5 |
| NHL | 2022/03/27 21:00 | BUF Sabres v NY Rangers | L | 4-5 |
| NHL | 2022/03/25 23:00 | WAS Capitals v BUF Sabres | L | 4-3 |
| NHL | 2022/03/23 23:30 | PIT Penguins v BUF Sabres | W | 3-4 |
| NHL | 2022/03/21 02:00 | BUF Sabres v VAN Canucks | W | 3-2 |