| Uruguay - Reserveliga | 2021/10/26 13:00 | Torque - Reserve v Atletico River Plate - Reserve | L | 2-1 |
| Uruguay - Reserveliga | 2021/10/18 18:30 | Atletico River Plate - Reserve v Penarol - Reserve | L | 0-5 |
| Uruguay - Reserveliga | 2021/10/04 18:30 | Rentistas - Reserve v Atletico River Plate - Reserve | D | 2-2 |
| Uruguay - Reserveliga | 2021/09/28 13:00 | Atletico River Plate - Reserve v Montevideo Wanderers - Reserve | L | 3-4 |
| Uruguay - Reserveliga | 2021/09/06 18:00 | Boston River - Reserve v Atletico River Plate - Reserve | W | 1-2 |
| Uruguay - Reserveliga | 2021/08/31 18:00 | Atletico River Plate - Reserve v Atletico Fenix - Reserve | L | 0-2 |
| Uruguay - Reserveliga | 2021/08/23 14:00 | Plaza Colonia - Reserve v Atletico River Plate - Reserve | W | 1-3 |
| Uruguay - Reserveliga | 2021/08/17 13:00 | Atletico River Plate - Reserve v Sud America - Reserve | W | 3-0 |
| Uruguay - Reserveliga | 2021/10/25 18:30 | Villa Española - Reserve v Liverpool Montevideo - Reserve | D | 0-0 |
| Uruguay - Reserveliga | 2021/10/19 18:30 | Cerrito - Reserve v Villa Española - Reserve | L | 2-1 |
| Uruguay - Reserveliga | 2021/10/04 18:30 | Villa Española - Reserve v Nacional de Montevideo - Reserve | L | 1-7 |
| Uruguay - Reserveliga | 2021/09/28 18:00 | Deportivo Maldonado - Reserve v Villa Española - Reserve | L | 4-2 |
| Uruguay - Reserveliga | 2021/09/07 18:00 | Torque - Reserve v Villa Española - Reserve | L | 2-0 |
| Uruguay - Reserveliga | 2021/08/23 16:00 | Rentistas - Reserve v Villa Española - Reserve | L | 3-2 |
| Uruguay - Reserveliga | 2021/08/03 18:00 | Boston River - Reserve v Villa Española - Reserve | D | 1-1 |
| Uruguay - Reserveliga | 2021/07/27 15:00 | Villa Española - Reserve v Atletico Fenix - Reserve | L | 1-3 |