[9] Sheff Wednesday 4-2 Plymouth [7] 2022-01-15 15:00
Stadion: Hillsborough Stadium Round: 28
Schiedsrichter: Christopher Pollard Home Manager: Darren Moore Away Manager: Steven Schumacher
Head to Head
| England - FA Cup | 2021/11/16 19:45 | Plymouth v Sheff Wednesday | L | 3-0 |
| England - FA Cup | 2021/11/07 12:15 | Sheff Wednesday v Plymouth | D | 0-0 |
| England - League 1 | 2021/09/11 14:00 | Plymouth v Sheff Wednesday | L | 3-0 |
Home History
| England - League 1 | 2022/01/02 15:00 | Shrewsbury v Sheff Wednesday | L | 1-0 |
| England - League 1 | 2021/12/30 19:45 | Sunderland v Sheff Wednesday | L | 5-0 |
| England - League 1 | 2021/12/11 15:00 | Crewe v Sheff Wednesday | W | 0-2 |
| England - League 1 | 2021/12/07 19:45 | Portsmouth v Sheff Wednesday | D | 0-0 |
| England - EFL Trophy | 2021/12/01 19:00 | Sheff Wednesday v Hartlepool | L | 0-3 |
| England - League 1 | 2021/11/27 15:00 | Sheff Wednesday v Wycombe | D | 2-2 |
| England - League 1 | 2021/11/23 19:45 | Sheff Wednesday v Milton Keynes Dons | W | 2-1 |
| England - League 1 | 2021/11/20 15:00 | Accrington Stanley v Sheff Wednesday | W | 2-3 |
Away History
| England - FA Cup | 2022/01/08 17:30 | Birmingham v Plymouth | W | 0-1 |
| England - League 1 | 2021/12/26 15:00 | Cheltenham v Plymouth | W | 0-2 |
| England - League 1 | 2021/12/18 15:00 | Plymouth v Charlton | W | 1-0 |
| England - League 1 | 2021/12/11 15:00 | Sunderland v Plymouth | L | 2-1 |
| England - League 1 | 2021/12/08 19:45 | Milton Keynes Dons v Plymouth | D | 1-1 |
| England - FA Cup | 2021/12/05 12:15 | Rochdale v Plymouth | W | 1-2 |
| England - League 1 | 2021/11/27 15:00 | Plymouth v Wigan | L | 1-2 |
| England - League 1 | 2021/11/23 19:45 | Plymouth v Wycombe | L | 0-3 |