[5] Tranmere 0-2 Northampton [6] 2021-10-23 14:00
Stadion: Prenton Park Round: 14
Schiedsrichter: Tom Nield Home Manager: Micky Mellon Away Manager: Jon Brady
Head to Head
| England - League 2 | 2019/02/05 19:45 | Tranmere v Northampton | L | 1-2 |
| England - League 2 | 2018/09/01 14:00 | Northampton v Tranmere | D | 1-1 |
| England - League 2 | 2015/03/14 15:00 | Northampton v Tranmere | L | 1-0 |
| England - League 2 | 2014/12/28 15:00 | Tranmere v Northampton | W | 2-1 |
Home History
| England - League 2 | 2021/10/19 18:45 | Harrogate Town v Tranmere | D | 2-2 |
| England - League 2 | 2021/10/16 14:00 | Carlisle v Tranmere | W | 0-1 |
| England - League 2 | 2021/10/08 18:45 | Tranmere v Colchester | W | 2-0 |
| England - EFL Trophy | 2021/10/05 18:00 | Salford City v Tranmere | W | 0-2 |
| England - League 2 | 2021/10/02 14:00 | Tranmere v Crawley Town | W | 2-1 |
| England - League 2 | 2021/09/25 14:00 | Forest Green v Tranmere | D | 0-0 |
| England - League 2 | 2021/09/18 14:00 | Tranmere v Salford City | W | 2-0 |
| England - EFL Trophy | 2021/09/14 18:00 | Tranmere v Leeds U21 | W | 4-1 |
Away History
| England - League 2 | 2021/10/19 18:45 | Northampton v Stevenage | W | 3-0 |
| England - League 2 | 2021/10/16 14:00 | Northampton v Mansfield | W | 2-0 |
| England - League 2 | 2021/10/09 14:00 | Hartlepool v Northampton | L | 2-1 |
| England - EFL Trophy | 2021/10/05 18:00 | Northampton v Walsall | L | 3-5 |
| England - League 2 | 2021/10/02 14:00 | Northampton v Sutton Utd | L | 0-2 |
| England - League 2 | 2021/09/25 14:00 | Salford City v Northampton | D | 2-2 |
| England - League 2 | 2021/09/18 13:00 | Northampton v Swindon | D | 1-1 |
| England - League 2 | 2021/09/14 18:45 | Newport County v Northampton | W | 0-1 |