[16] Serena Williams 6-4,3-6,8-10 Venus Williams [38] 2018-12-27 16:05
Round: 29 Ground: Hardcourt outdoor
Head to Head
| US Open - Damen | 2018/09/01 00:00 | Serena Williams v Venus Williams | 6-1,6-2 |
| WTA - Indian Wells | 2018/03/13 02:10 | Venus Williams v Serena Williams | 6-3,6-4 |
| Australian Open 2017 - Damen | 2017/01/28 08:30 | Venus Williams v Serena Williams | 4-6,4-6 |
| Wimbledon - Damen | 2015/07/06 12:00 | Serena Williams v Venus Williams | 6-4,6-3 |
| WTA - Montreal | 2014/08/09 17:00 | Serena Williams v Venus Williams | 7-6,2-6,3-6 |
Home History
| US Open - Damen | 2018/09/08 20:00 | Serena Williams v Naomi Osaka | 2-6,4-6 |
| US Open - Damen | 2018/09/06 23:10 | Serena Williams v Anastasija Sevastova | 6-3,6-0 |
| US Open - Damen | 2018/09/04 23:10 | Serena Williams v Karolina Pliskova | 6-4,6-3 |
| US Open - Damen | 2018/09/02 19:45 | Kaia Kanepi v Serena Williams | 0-6,6-4,3-6 |
| US Open - Damen | 2018/09/01 00:00 | Serena Williams v Venus Williams | 6-1,6-2 |
| US Open - Damen | 2018/08/29 23:05 | Serena Williams v Carina Witthöft | 6-2,6-2 |
| US Open - Damen | 2018/08/28 00:00 | Serena Williams v Magda Linette | 6-4,6-0 |
| WTA - Cincinnati | 2018/08/15 00:30 | Petra Kvitova v Serena Williams | 6-3,2-6,6-3 |
Away History
| US Open - Damen | 2018/09/01 00:00 | Serena Williams v Venus Williams | 6-1,6-2 |
| US Open - Damen | 2018/08/29 17:00 | Camila Giorgi v Venus Williams | 4-6,5-7 |
| US Open - Damen | 2018/08/27 18:45 | Svetlana Kuznetsova v Venus Williams | 3-6,7-5,3-6 |
| WTA - Montreal | 2018/08/10 00:40 | Simona Halep v Venus Williams | 6-2,6-2 |
| WTA - Montreal | 2018/08/09 17:45 | Sorana Cirstea v Venus Williams | 6-7,4-6 |
| WTA - Montreal | 2018/08/06 19:30 | Caroline Dolehide v Venus Williams | 5-7,1-6 |
| WTA - San Jose | 2018/08/04 02:00 | Venus Williams v Maria Sakkari | 4-6,6-7 |
| WTA - San Jose | 2018/08/03 02:00 | Venus Williams v Heather Watson | 6-4,4-6,6-0 |